2015-2017

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Markus Toegel, Ghows Azzam, Eunice Y. Lee, David J. H. F. Knapp, Ying Tan, Ming Fa & Tudor A. Fulga
Nature Commun. 2017 Nov 21;8(1):1663. doi:10.1038/s41467-017-01592-3.
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Engineering Synthetic Signaling Pathways with Programmable dCas9-Based Chimeric Receptors.
Baeumler TA, Ahmed AA, Fulga TA.
Cell Rep. 2017 Sep 12;20(11):2639-2653. doi: 10.1016/j.celrep.2017.08.044.
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Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs.
Ferry QRV, Lyutova R, Fulga TA.
Nature Commun 2017 Mar 3;8:14633. doi: 10.1038/ncomms14633.
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Interrogation of Functional miRNA-Target Interactions by CRISPR/Cas9 Genome Engineering.
Michaels YS, Wu Q, Fulga TA
Methods Mol Biol. 2017 1580:79-97. doi: 10.1007/978-1-4939-6866-4_7.
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Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.
Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK.
PNAS. 2016 Aug 9;113(32):E4688-97. doi: 10.1073/pnas.1523597113.
pubmed

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Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase.
Reilly SN, Liu X, Carnicer R, Recalde A, Muszkiewicz A, Jayaram R, Carena MC, Wijesurendra R, Stefanini M, Surdo NC, Lomas O, Ratnatunga C, Sayeed R, Krasopoulos G, Rajakumar T, Bueno-Orovio A, Verheule S, Fulga TA, Rodriguez B, Schotten U, Casadei B.
Sci Transl Med. 2016 May 25;8(340):340ra74. doi: 10.1126/scitranslmed.aac4296.
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Tiny giants of gene regulation: experimental strategies for microRNA functional studies.
Steinkraus BR, Toegel M, Fulga TA.
Wiley Interdiscip Rev Dev Biol.2016. May-Jun;5(3):311-62. doi: 10.1002/wdev.223.
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ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts.
Valletta S, Dolatshad H, Bartenstein M, Yip BH, Bello E, Gordon S, Yu Y, Shaw J, Roy S, Scifo L, Schuh A, Pellagatti A, Fulga TA, Verma A, Boultwood J.
Oncotarget. 2015 Dec 29;6(42):44061-71. doi: 10.18632/oncotarget.6392.
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microRNAs that promote or inhibit memory formation in Drosophila melanogaster.
Busto GU, Guven-Ozkan T, Fulga TA, Van Vactor D, Davis RL.
Genetics 2015 Jun;200(2):569-80 doi: 10.1534/genetics.114.169623.
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A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs.
Fulga TA, McNeill EM, Binari R, Yelick J, Blanche A, Booker M, Steinkraus BR, Schnall-Levin M, Zhao Y, DeLuca T, Bejarano F, Han Z, Lai EC, Wall DP, Perrimon N, Van Vactor D.
Nature Comm. 2015 Jun 17;6:7279. doi: 10.1038/ncomms8279.
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microRNA-dependent transcriptional silencing of transposable elements in Drosophila follicle cells.
Mugat B, Akkouche A, Serrano V, Armenise C, Li B, Brun C, Fulga TA, Van Vactor D, Pélisson A, Chambeyron S.
PLoS Genet. 2015 May 19;11(5):e1005194. doi: 10.1371/journal.pgen.1005194.
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Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau.
Santa-Maria I, Alaniz ME, Renwick N, Cela C, Fulga TA, Van Vactor D, Tuschl T, Clark LN, Shelanski ML, McCabe BD, Crary JF.
J Clin Invest. 2015 Feb;125(2):681-6 doi: 10.1172/JCI78421.
pubmed

2010-2014

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Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7.
Tan JY, Vance KW, Varela MA, Sirey T, Watson LM, Curtis HJ, Marinello M, Alves S, Steinkraus BR, Cooper S, Nesterova T, Brockdorff N, Fulga TA, Brice A, Sittler A, Oliver PL, Wood MJ, Ponting CP, Marques AC.
Nat Struct Mol Biol. 2014 Nov;21(11):955-61 doi: 10.1038/nsmb.2902.
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Understanding functional miRNA-target interactions in vivo by site-specific genome engineering.
Bassett AR, Azzam G, Wheatley L, Tibbit C, Rajakumar T, McGowan S, Stanger N, Ewels PA, Taylor S, Ponting CP, Liu JL, Sauka-Spengler T, Fulga TA.
Nature Comm. 2014 Aug 19;5:4640. doi: 10.1038/ncomms5640.
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BDNF promotes axon branching of retinal ganglion cells via miRNA-132 and p250GAP.
Marler KJ, Suetterlin P, Dopplapudi A, Rubikaite A, Adnan J, Maiorano NA, Lowe AS, Thompson ID, Pathania M, Bordey A, Fulga T, Van Vactor DL, Hindges R, Drescher U.
J Neurosci. 2014 Jan 15;34(3):969-79. doi: 10.1523/JNEUROSCI.1910-13.2014.
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MicroRNA-276a functions in ellipsoid body and mushroom body neurons for naive and conditioned olfactory avoidance in Drosophila.
Li W, Cressy M, Qin H, Fulga T, Van Vactor D, Dubnau J.
J Neurosci. 2013 Mar 27;33(13):5821-33. doi: 10.1523/JNEUROSCI.4004-12.2013.
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A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.
Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou YT, Raleigh DR, Kim K, Ni JQ, Duan H, Yang JS, Fulga TA, Van Vactor D, Perrimon N, Lai EC.
Development. 2012 Aug;139(15):2821-31. doi: 10.1242/dev.079939. Epub 2012 Jun 28.
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A neuroprotective role for the DNA damage checkpoint in tauopathy.
Khurana V, Merlo P, DuBoff B, Fulga TA, Sharp KA, Campbell SD, Götz J, Feany MB.
Aging Cell. 2012 Apr;11(2):360-2. doi: 10.1111/j.1474-9726.2011.00778.x. Epub 2012 Feb 1. doi: 10.1111/j.1474-9726.2011.00778.x. Epub 2012 Feb 1.
pubmed

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Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB.
PLoS Genet. 2010 Jul 15;6(7):e1001026. doi: 10.1371/journal.pgen.1001026.
pubmed

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Understanding neuronal connectivity through the post-transcriptional toolkit.
Loya CM, Van Vactor D, Fulga TA.
Genes Dev. 2010 Apr 1;24(7):625-35. doi: 10.1101/gad.1907710.
pubmed

2002-2009

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Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms.
Loya CM, Lu CS, Van Vactor D, Fulga TA.
Nat Methods. 2009 Dec;6(12):897-903. doi: 10.1038/nmeth.1402. Epub 2009 Nov 15.
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Synapses and growth cones on two sides of a highwire.
Fulga TA, Van Vactor D.
Neuron. 2008 Feb 7;57(3):339-44. doi: 10.1016/j.neuron.2008.01.016.
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Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.
Steinhilb ML, Dias-Santagata D, Fulga TA, Felch DL, Feany MB.
Mol Biol Cell. 2007 Dec;18(12):5060-8. Epub 2007 Oct 10.
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Two distinct modes of guidance signalling during collective migration of border cells.
Bianco A, Poukkula M, Cliffe A, Mathieu J, Luque CM, Fulga TA, Rørth P.
Nature. 2007 Jul 19;448(7151):362-5.
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Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.
Periquet M, Fulga T, Myllykangas L, Schlossmacher MG, Feany MB.
J Neurosci. 2007 Mar 21;27(12):3338-46.
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Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB.
Nat Cell Biol. 2007 Feb;9(2):139-48. Epub 2006 Dec 24.
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Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
Dias-Santagata D, Fulga TA, Duttaroy A, Feany MB.
J Clin Invest. 2007 Jan;117(1):236-45. Epub 2006 Dec 14.
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Senseless makes sense for spinocerebellar ataxia-1.
Khurana V, Fulga TA, Feany MB.
Nat Neurosci. 2005 Nov;8(11):1422-4.
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Invasive cell migration is initiated by guided growth of long cellular extensions.
Fulga TA, Rørth P.
Nat Cell Biol. 2002 Sep;4(9):715-9.
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Distinct modes of signal recognition particle interaction with the ribosome.
Pool MR, Stumm J, Fulga TA, Sinning I, Dobberstein B.
Science. 2002 Aug 23;297(5585):1345-8.
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SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon.
Fulga TA, Sinning I, Dobberstein B, Pool MR.
EMBO J. 2001 May 1;20(9):2338-47.
pubmed